Smart polyhydroxyalkanoate nanobeads by protein based functionalization
نویسندگان
چکیده
منابع مشابه
Functionalization of protein-based nanocages for drug delivery applications.
Traditional drug delivery strategies involve drugs which are not targeted towards the desired tissue. This can lead to undesired side effects, as normal cells are affected by the drugs as well. Therefore, new systems are now being developed which combine targeting functionalities with encapsulation of drug cargo. Protein nanocages are highly promising drug delivery platforms due to their perfec...
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Bacteria capable of degrading polyhydroxyalkanoates (PHA) by secreting extracellular depolymerase enzymes were isolated from water and soil samples collected from various environments in Malaysia. A total of 8 potential degraders exhibited clear zones on poly(3-hydroxybutyrate) [P(3HB)] based agar, indicating the presence of extracellular PHA depolymerase. Among the isolates, DP5 exhibited the ...
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Simple and sensitive detection of infectious disease at an affordable cost is urgently needed in developing nations. In this regard, the dot blot immunoassay has been used as a common protein detection method for detection of disease markers. However, the traditional signal reporting systems, such as those using enzymes or gold nanoparticles lack sensitivity and thus restrict the application of...
متن کاملEnzymatic synthesis of a drug delivery system based on polyhydroxyalkanoate-protein block copolymers.
A new approach to prepare functional polymeric micelles in a one step reaction using the unique catalytic property of PHA synthase is described. A biopolymer-based nanocarrier with cancer targeting capability was successfully synthesized from genetically engineered PHA synthase fused with RGD peptide.
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Abstract Background and Objective: Magnetic nanobeads have a large surface- area-to-volume ratio, which is used for immobilized antibody. Using nanoparticles could increase the amount of antibodies in surface in comparison to ELISA. We investigated the ability of magnetic nanobeads to evaluate CRP by colorimetric method and compared the results with ELISA. Material and Methods: This stud...
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ژورنال
عنوان ژورنال: Nanomedicine: Nanotechnology, Biology and Medicine
سال: 2015
ISSN: 1549-9634
DOI: 10.1016/j.nano.2015.01.018